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Predicting second-round 2025 NCAA Tournament upsets: VCU looks deadly, No. 1s safe

Predicting second-round 2025 NCAA Tournament upsets: VCU looks deadly, No. 1s safe


For the past two days, we’ve broken down first-round matchups in our annual search for upsets. But brackets don’t stop after one round. And here at Bracket Breaker Central, we are eternally at your service. So, we present the upset odds for every potential second-round matchup that qualifies for Bracket Breaker status (i.e., a difference of at least five seeds).

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A few notes before you dive into the data:

  • VCU over Wisconsin is far and away the best shot at a second-round upset, coming in at close to 50 percent. If you’re going to take the Rams to beat BYU, you might as well pick them over the Badgers as well.
  • Not a single No. 8 or No. 9 seed even reaches 20 percent upset odds against a No. 1 seed. That’s a testament to the strength of the top teams this year.
  • UCLA and Utah State both have outstanding “killer” profiles. The Bruins force turnovers at the nation’s seventh-highest rate, while the Aggies excel in that area as well (38th in the nation) while also grabbing offensive rebounds and shooting plenty of 3s. Regardless of which team wins, Tennessee will face a stiffer challenge than many people realize.
  • Don’t sleep on Kansas. The Jayhawks have struggled mightily, but every year, a team takes its lumps in a power conference only to mount a rally in the NCAA Tournament. We call these teams “wounded assassins,” and you only need to look back to last year’s North Carolina State squad for a recent example. If the Jayhawks survive Arkansas — no easy task — they have a 23 percent chance of upsetting St. John’s.
  • A pair of No. 3 seeds — Iowa State and Kentucky — look vulnerable, with upset odds over 25 percent. And that doesn’t account for the Cyclones’ injury to Keshon Gilbert.

Bracket Breakers Regional Breakdowns
West  | South | Midwest | East
Women’s Top 10 Upsets

Want a closer look at the first round? Check out the regional breakdowns above. And now, on to the second-round numbers!

South Region

Potential Matchup Upset Chance

No. 1 Auburn vs. No. 8 Louisville

14.5%

No. 1 Auburn vs. No. 9 Creighton

15.6%

No. 2 Michigan St. vs. No. 7 Marquette

33.0%

No. 2 Michigan St. vs. No. 10 New Mexico

21.3%

No. 3 Iowa State vs. No. 11 North Carolina

27.6%

No. 4 Texas A&M vs. No. 12 UC San Diego

21.0%

No. 5 Michigan vs. No. 13 Yale

16.2%

No. 6 Mississippi vs. No. 14 Lipscomb

26.0%

No. 7 Marquette vs. No. 15 Bryant

7.4%

No. 8 Louisville vs. No. 16 Alabama St.

4.6%

No. 9 Creighton vs. No. 16 Alabama St.

16.1%

No. 10 New Mexico vs. No. 15 Bryant

13.3%

West Region

Potential Matchup Upset Chance

No. 1 Florida vs. No. 8 UConn

15.5%

No. 1 Florida vs. No. 9 Oklahoma

8.3%

No. 2 St. John’s vs. No. 7 Kansas

22.8%

No. 2 St. John’s vs. No. 10 Arkansas

16.1%

No. 3 Texas Tech vs. No. 11 Drake

26.4%

No. 4 Maryland vs. No. 12 Colorado St.

20.4%

No. 5 Memphis vs. No. 13 Grand Canyon

21.1%

No. 6 Missouri vs. No. 14 UNC Wilmington

18.9%

No. 7 Kansas vs. No. 15 Omaha

5.6%

No. 8 UConn vs. No. 16 Norfolk St.

8.9%

No. 9 Oklahoma vs. No. 16 Norfolk St.

23.9%

No. 10 Arkansas vs. No. 15 Omaha

13.8%

East Region

Potential Matchup Upset Chance

No. 1 Duke vs. No. 8 Mississippi St.

12.1%

No. 1 Duke vs. No. 9 Baylor

17.2%

No. 2 Alabama vs. No. 7 St. Mary’s

16.5%

No. 2 Alabama vs. No. 10 Vanderbilt

22.7%

No. 3 Wisconsin vs. No. 11 VCU

44.3%

No. 4 Arizona vs. No. 12 Liberty

17.2%

No. 5 Oregon vs. No. 13 Akron

20.3%

No. 6 BYU vs. No. 14 Montana

6.8%

No. 7 St. Mary’s vs. No. 15 Robert Morris

16.0%

No. 8 Mississippi State vs. No. 16 American

12.0%

No. 8 Mississippi State vs. No. 16 Mount St. Mary’s

9.3%

No. 9 Baylor vs. No. 16 American

12.7%

No. 9 Baylor vs. No. 16 Mount St. Mary’s

8.5%

No. 10 Vanderbilt vs. No. 15 Robert Morris

19.3%

Midwest Region

Potential Matchup Upset Chance

No. 1 Houston vs. No. 8 Gonzaga

11.9%

No. 1 Houston vs. No. 9 Georgia

14.5%

No. 2 Tennessee vs. No. 7 UCLA

25.2%

No. 2 Tennessee vs. No. 10 Utah St.

25.1%

No. 3 Kentucky vs. No. 11 Texas

36.0%

No. 3 Kentucky vs. No. 11 Xavier

28.4%

No. 4 Purdue vs. No. 12 McNeese

29.6%

No. 5 Clemson vs. No. 13 High Point

22.0%

No. 6 Illinois vs. No. 14 Troy

23.2%

No. 7 UCLA vs. No. 15 Wofford

14.6%

No. 8 Gonzaga vs. No. 16 SIU Edwardsville

7.6%

No. 9 Georgia vs. No. 16 SIU Edwardsville

8.3%

No. 10 Utah St. vs. No. 15 Wofford

15.5%

(Photo: G Fiume / Getty Images; Illustration: Will Tullos, The Athletic)



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